A team from the University of Saskatchewan ( UofS ) directed by Keith Bonham discovered a mechanism of genetic regulation that could explicate why diets elevated doses of fiber authority body avoided by those suffering from cancer of the colon.
A gang from the University of Saskatchewan ( UofS ) directed by Keith Bonham discovered a mechanism of genetic regulation that could unfold why diets steep doses of fiber encumbrance enact avoided by those suffering from cancer of the colon.
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Leadership an article recently published reputation the magazine Oncogene, UofS team gives insight into his new job on a certain class of drugs known as Histone Deacetylase Inhibitors.
Scientists have long looked at the links that might exist between the schemes strong fiber and colon cancer. He is also known that in cancer, a gene called SRC is responsible for uncontrolled cell where malfunction. The hope lies in the possibility of preventing the SRC gene is over - expressed.
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Working with human cell cultures, the team of Dr. Bonham was found that the SRC gene could be " turned off " by a fatty acid that appears so natural, sodium butyrate, which is generated in the colon by fermentation of fibers. Butyrate reduced the level of SRC in cells by inhibiting the action of the enzyme histone deacetylase.
In contrast to the colon, breast or liver are not body parts exposed to high doses of butyrate in a natural way, however, the team discovered UofS a drug such as trichostatin A ( TSA ), known to be a histone deacetylase inhibitor, inhibit the activity of SRC in the same manner as butyrate in these areas of the body likely to develop cancerous cells.
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This information is an excerpt from BE Canada number 209 of 16 / 09 / 2002 prepared by the Embassy of France in Canada. Bulletins Electroniques ( BE ) sont un service ADIT et sont accessibles gratuitement
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